Translational genomics of neurodevelopmental disorders
Welcome to our lab site!
We are a highly motivated and interdisciplinary research team that focuses on dissecting molecular networks and mechanisms underlying human brain function and disease, using the fruitfly Drosophila melanogaster as a model. Here you can read more about what we do.
We are based in the Department of Human Genetics at Radboudumc in Nijmegen, The Netherlands. In addition, we are embedded in the multidisciplinary Donders institute of Brain, Cognition, and Behaviour, which allows us to operate across disciplines.
Recent highlights
2025
March 8 - We joined the strike against the terrible budget cuts to higher education and research. With our signs "Steun Onderwijs & Onderzoek voor een sterk Europa" and "Slim budgetteren kán je leren", we fully support the relay strike's slogan: DOE HET NIET!
Feb - The February edition of the Radbode (the journal of the Radboudumc) featured an article on the GTF3C3 paper by Laura, Adela and Mireia, including interviews with Annette and a patient's parent.
Feb - We sadly said goodbye to our technician Franziska, but were happy to welcome previous intern Pleuni as our new technician! We wish Franziska a great time at her new position at the MPI in Münster.
Jan 24 - Part of the lab joined for the REPURPOLIS Drug Repurposing Game, organized by Eatris; a game about the path to successfully bring a repurposing drug candidate from academia to the patient. Very fun and insightful.
More news here
Events we look forward to
March-June - Nicholas is visiting the Préat & Plaçais group in Paris to learn live imaging and to identify metabolic dysregulation associated with several neurodevelopmental genes.
April 3-5 - Marina will (digitally) join the Genetics of Neurodevelopmental Disorders conference and present a talk
April 9 - Barbara, Isabel, Spencer and Marina team up for the Carréloop - a relay run through the basement of the Radboudumc.
April 22 - we sadly say goodbye to Melanie, who was part of the lab for 2 years as an intern and as student assistent. We will get together for a fun night of bowling and drinks.
June 5-6 - Annette will present at the Kleefstra Syndrome Confererence 2025 in Spain.
June 19 - Annette will give a presentation at the FOXP1 conference in Ijmuiden.
Sept 25-28 - The European Drosophila Research Conference in Alicante! Nicholas will participate, and Annette will co-chair the session on disease models.
2026
Sept - Neurofly '26 in Cologne! Annette is involved in the organization.
